Opportunity Information: Apply for RFA AG 18 017
The National Institutes of Health (NIH) funding opportunity titled "Central Neural Mechanisms of Age-Related Hearing Loss (R01)" (Funding Opportunity Number RFA-AG-18-017) supports grant applications that focus on how the brain and central auditory system contribute to age-related hearing loss. It is set up to encourage both basic and clinical research that looks beyond the ear itself and instead digs into the central pathways, brain networks, and neural processing changes that may drive or worsen hearing difficulties in older adults. The core idea is that age-related hearing loss is not only about damage in the peripheral auditory system (like the cochlea), but also about how aging affects the brain structures and circuits that interpret sound, adapt to auditory input, and compensate for sensory changes over time.
A central motivation behind this FOA is that there is still a major knowledge gap in understanding the "central" side of age-related hearing loss, meaning the neural circuits that carry, transform, and interpret sound signals once they enter the brain. The announcement emphasizes research aimed at identifying which central auditory pathways and broader neural networks are involved, how these systems may be altered as the brain ages, and how aging influences central auditory plasticity. In practical terms, this includes studying how the aging brain changes its ability to reorganize, adapt, or recalibrate in response to degraded auditory input, and how those changes might relate to real-world hearing challenges older adults experience, such as difficulty understanding speech in noisy environments, slower auditory processing, or problems with sound localization.
The FOA supports studies in older adult populations and also welcomes work in relevant animal models, recognizing that animal research can allow detailed investigation of neural mechanisms that are difficult to measure directly in humans. By encouraging both clinical and preclinical approaches, the program aims to connect mechanistic neuroscience to outcomes that matter for aging individuals, potentially helping shape future interventions that address not just amplification (for example, hearing aids) but also the brain-based processing and adaptation issues that might limit benefit from peripheral devices.
This is an R01 grant mechanism, meaning it is intended for substantial, hypothesis-driven research projects with a defined scientific plan. The opportunity is categorized as discretionary funding and falls under the NIH health research mission. The CFDA numbers associated with the program are 93.173 and 93.866, reflecting its placement within NIH-supported research areas tied to aging and related biomedical topics. The listed award ceiling is $500,000, indicating the upper limit presented in the opportunity summary for budget planning purposes.
Eligibility is broad and includes many types of U.S.-based organizations and governmental units, such as state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; and public housing authorities, including Indian housing authorities. It is also open to Native American tribal governments that are federally recognized, as well as Native American tribal organizations that are not federally recognized tribal governments. Nonprofit organizations are eligible whether or not they have 501(c)(3) status (as long as they are not institutions of higher education), and both for-profit organizations (other than small businesses) and small businesses are listed as eligible applicants. The FOA also explicitly highlights additional eligible applicant categories, including Alaska Native and Native Hawaiian Serving Institutions; Asian American, Native American, and Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible agencies of the federal government; U.S. territories or possessions; regional organizations; and even non-domestic (non-U.S.) entities (foreign organizations). This wide eligibility reflects an intention to draw in diverse institutions and research environments, including those serving populations that are often underrepresented in biomedical research.
Key administrative details included in the source summary are that the opportunity was created on July 18, 2017, and the original closing date was November 8, 2017. The sponsoring agency is the National Institutes of Health. While the summary does not list the expected number of awards, the emphasis of the announcement is clearly on advancing the neuroscience of age-related hearing loss by focusing on central mechanisms, brain aging, and the capacity for neural plasticity in auditory systems. In short, this FOA targets research that can explain how aging reshapes auditory brain function and, over time, contribute to better strategies for diagnosis, prevention, and treatment of hearing problems in older adults.Apply for RFA AG 18 017
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Central Neural Mechanisms of Age-Related Hearing Loss (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173, 93.866.
- This funding opportunity was created on 2017-07-18.
- Applicants must submit their applications by 2017-11-08. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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