Opportunity Information: Apply for RFA AI 19 074
The Childhood Asthma in Urban Settings Clinical Research Network - Leadership Center (CAUSE-LC) funding opportunity (RFA AI 19 074) is a National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID) cooperative agreement intended to establish a single Leadership Center that will direct and coordinate a broader clinical research network focused on childhood asthma in low-income urban environments. The award mechanism is a UM1 cooperative agreement and it is explicitly designated as a clinical trial required opportunity, meaning the funded Leadership Center is expected to help enable and oversee the planning and conduct of multi-site clinical studies and clinical trials rather than purely observational or basic research activities.
At its core, the Leadership Center is meant to serve as the hub for the CAUSE Clinical Research Network. Its main role is to provide the overall scientific strategy and the organizational structure needed to run a coordinated, multi-site program of research. In practice, this means the CAUSE-LC would work closely with multiple CAUSE Clinical Research Centers (CAUSE-CRCs) to support the design, launch, and management of network-wide studies and trials. The emphasis is on producing actionable evidence that can lead to effective interventions or even prevention approaches that are realistically applicable to children living in low-income urban settings, where asthma burden and related environmental and social risk factors are often higher and more complex.
Because this is a cooperative agreement rather than a standard research grant, the federal government anticipates substantial involvement from NIAID staff in the conduct and oversight of the program. The Leadership Center is therefore expected not only to propose a scientific vision, but also to demonstrate strong operational capacity for network coordination, cross-site collaboration, and consistent implementation of protocols across multiple participating research centers. The outcome NIAID is aiming for is a well-run, centrally guided network capable of executing rigorous multi-site clinical research that directly addresses asthma outcomes and prevention strategies relevant to urban pediatric populations experiencing socioeconomic disadvantage.
Eligibility for this opportunity is broad and includes many types of domestic organizations: state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding higher education institutions in those categories); for-profit organizations other than small businesses; small businesses; and additional applicants as described in the full announcement. This range of eligible applicants reflects the expectation that leadership and coordination for a large clinical research network could be housed in universities, medical centers, nonprofit research institutions, or other entities with sufficient infrastructure and clinical research experience.
The FOA was published by the U.S. Department of Health and Human Services under NIH, with a creation date of January 29, 2020, and an original application due date of June 19, 2020. NIAID anticipated making a single award (ExpectedAwards: 1), underscoring that this is a central leadership and coordinating function for the entire network rather than a distributed set of multiple leadership awards. The listed award ceiling is shown as 0, which typically indicates that applicants should consult the full FOA for budget guidance and that a fixed cap may not be specified in the summary fields.
In short, this opportunity funds one Leadership Center to set the scientific direction and manage the operations of a multi-site clinical research network dedicated to improving asthma-related interventions and prevention strategies for children in low-income urban settings, working in close partnership with participating clinical research centers and under a cooperative agreement structure with active involvement from NIAID.Apply for RFA AI 19 074
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Childhood Asthma in Urban Settings Clinical Research Network- Leadership Center (UM1 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855.
- This funding opportunity was created on Jan 29, 2020.
- Applicants must submit their applications by Jun 19, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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FAQs: Childhood Asthma in Urban Settings Clinical Research Network - Leadership Center (CAUSE-LC) (RFA AI 19 074)
What is the CAUSE-LC funding opportunity?
CAUSE-LC (RFA AI 19 074) is a National Institutes of Health (NIH) funding opportunity from the National Institute of Allergy and Infectious Diseases (NIAID) to establish a single Leadership Center that directs and coordinates a broader clinical research network focused on childhood asthma in low-income urban environments.
Which NIH institute is sponsoring this opportunity?
The opportunity is sponsored by NIH's National Institute of Allergy and Infectious Diseases (NIAID), within the U.S. Department of Health and Human Services (HHS).
What does CAUSE-LC stand for?
CAUSE-LC refers to the Childhood Asthma in Urban Settings Clinical Research Network - Leadership Center.
What is the main purpose of the Leadership Center?
The Leadership Center serves as the hub for the CAUSE Clinical Research Network. It is responsible for the overall scientific strategy and the organizational structure needed to run a coordinated, multi-site program of research in childhood asthma in low-income urban settings.
How many Leadership Centers will be funded?
NIAID anticipated making a single award (ExpectedAwards: 1). This reflects the intent to fund one central leadership and coordination hub for the entire network.
What type of award mechanism is used?
The award mechanism is a UM1 cooperative agreement.
What does it mean that this is a cooperative agreement?
Because it is a cooperative agreement (rather than a standard research grant), NIAID expects substantial involvement by NIAID staff in the conduct and oversight of the program. The Leadership Center must be prepared to work closely with NIAID as part of network operations and governance.
Is a clinical trial required under this opportunity?
Yes. The opportunity is explicitly designated as "clinical trial required," meaning the funded Leadership Center is expected to enable and oversee the planning and conduct of multi-site clinical studies and clinical trials (not only observational or basic research).
What kind of research activities is the network expected to support?
The network is expected to support rigorous, multi-site clinical research, including clinical studies and clinical trials, that produce actionable evidence for interventions or prevention approaches relevant to childhood asthma in low-income urban settings.
What population and setting are the focus of this network?
The focus is on children with asthma in low-income urban environments, where asthma burden and related environmental and social risk factors are often higher and more complex.
What outcomes is NIAID aiming for?
NIAID is aiming for a well-run, centrally guided network capable of executing rigorous multi-site clinical research that directly addresses asthma outcomes and prevention strategies relevant to urban pediatric populations experiencing socioeconomic disadvantage.
How does the Leadership Center interact with other sites in the network?
The Leadership Center is expected to work closely with multiple CAUSE Clinical Research Centers (CAUSE-CRCs) to support the design, launch, and management of network-wide studies and trials, and to enable cross-site collaboration and consistent implementation of study protocols.
What operational capabilities are expected from the Leadership Center?
The Leadership Center is expected to demonstrate strong operational capacity for network coordination, cross-site collaboration, and consistent implementation of protocols across multiple participating research centers, alongside proposing a clear scientific vision.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic organizations, including:
- State, county, city, or township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments and other tribal organizations
- Public housing authorities and Indian housing authorities
- Nonprofits with or without 501(c)(3) status (excluding higher education institutions in those nonprofit categories)
- For-profit organizations other than small businesses
- Small businesses
- Additional applicant types as described in the full announcement
Are applicants limited to universities or medical centers?
No. While universities, medical centers, and nonprofit research institutions are common candidates for this type of role, the eligibility list is broad and includes government entities, tribal organizations, housing authorities, nonprofits, for-profits, and small businesses, as long as they can provide the infrastructure and clinical research experience needed to lead and coordinate a network.
Is this opportunity intended to fund multiple sites directly?
The summary indicates a single award to fund one Leadership Center. The Leadership Center is expected to coordinate a broader network that includes multiple CAUSE Clinical Research Centers (CAUSE-CRCs) participating in network-wide studies and trials.
When was the funding opportunity published?
The FOA creation date is January 29, 2020.
What was the original application due date?
The original application due date listed is June 19, 2020.
Which department issued the FOA?
The FOA was published by the U.S. Department of Health and Human Services (HHS) under NIH.
How much funding is available and is there an award ceiling?
The listed award ceiling is shown as 0 in the summary fields, which typically indicates that a fixed cap may not be specified there and applicants should consult the full FOA for budget guidance.
What is the overall goal of CAUSE-LC in practical terms?
In practical terms, the goal is to fund one Leadership Center that sets scientific direction, builds and maintains the organizational structure for the network, and manages coordinated multi-site clinical studies and trials aimed at improving interventions and prevention strategies for childhood asthma in low-income urban settings, with active NIAID involvement.
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