Opportunity Information: Apply for RFA CA 22 057
The National Cancer Institute (NCI), part of the National Institutes of Health (NIH), is offering an R21 grant opportunity titled "Basic/Translational Research on Health Disparities in Underrepresented People Living with HIV (PLWH) and Cancer (R21 Clinical Trial Not Allowed)" under funding opportunity number RFA-CA-22-057 (CFDA 93.396). This opportunity supports discretionary grant funding in the broad areas of health and education, with a specific scientific focus on understanding why cancer burdens and outcomes differ in people living with HIV who are also members of underrepresented minority groups.
The central purpose of the announcement is to fund basic mechanistic and translational research that examines how HIV interacts with the conditions that create or worsen health disparities to influence cancer development and outcomes. The emphasis is on biological interactions: projects should dig into the mechanisms by which HIV, in combination with disparity-related factors, contributes to the initiation and progression of both AIDS-defining cancers and non-AIDS-defining cancers, as well as the downstream disease complications and pathogenic sequelae that follow. In practical terms, the NCI is looking for studies that can connect disparities and HIV biology to cancer risk, tumor behavior, immune or inflammatory changes, co-infections, treatment responses, or other mechanistically grounded pathways that could explain unequal cancer outcomes in these populations.
The grant mechanism is the NIH R21, which is commonly used to support exploratory and developmental projects that may be higher-risk but have the potential to open new directions for the field. The announcement explicitly states "Clinical Trial Not Allowed," meaning applicants should not propose studies that meet the NIH definition of a clinical trial. The intent is to keep the work in the realm of basic and translational research rather than interventional testing in human subjects designed to evaluate health outcomes. That said, translational studies can still include work that bridges laboratory findings toward human relevance, as long as the proposed research does not constitute a clinical trial.
Eligibility is broad and includes many kinds of organizations that might be positioned to address HIV, cancer, and disparity-focused research. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; and both federally recognized Native American tribal governments and other tribal organizations that are not federally recognized. The opportunity is also open to public housing authorities/Indian housing authorities, nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education), for-profit organizations (other than small businesses), and small businesses. In addition, the announcement highlights other eligible applicants such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations). This breadth signals an interest in drawing on institutions and partnerships that are closely connected to underrepresented communities and the real-world contexts in which disparities are produced and experienced.
Key administrative details include an original closing date of December 15, 2023, and an award ceiling listed as $275,000. The posting indicates expected awards but does not provide a specific number in the provided source text. The opportunity was created on October 3, 2022. Overall, this FOA is aimed at catalyzing mechanistic and translational insights into how HIV and disparity-related factors combine to drive unequal cancer outcomes in underrepresented populations, with the longer-term goal of building a stronger biological foundation for future prevention, diagnosis, and treatment strategies that can reduce cancer health disparities among people living with HIV.Apply for RFA CA 22 057
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Basic/Translational Research on Health Disparities in Underrepresented People Living with HIV (PLWH) and Cancer (R21 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.396.
- This funding opportunity was created on 2022-10-03.
- Applicants must submit their applications by 2023-12-15. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $275,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| NIDA REI: Reaching Equity at the Intersection of HIV and Substance Use: Novel Approaches to Address HIV Related Health Disparities in Underserved Racial and/or Ethnic Populations (R34 Clinical Trial Optional) Apply for RFA DA 23 062 Funding Number: RFA DA 23 062 Agency: National Institutes of Health Category: Education, Health Funding Amount: $450,000 |
| Basic/Translational Research on Health Disparities in Underrepresented People Living with HIV (PLWH) and Cancer (R01 Clinical Trial Not Allowed) Apply for RFA CA 22 056 Funding Number: RFA CA 22 056 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NLM Research Grants in Biomedical Informatics and Data Science (R01 Clinical Trial Optional) Apply for PAR 23 034 Funding Number: PAR 23 034 Agency: National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| AHEAD (Advancing Head and Neck Cancer Early Detection Research) (U01 Clinical Trial Not Allowed) Apply for RFA DE 23 013 Funding Number: RFA DE 23 013 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Avenir Award Program for Chemistry and Pharmacology of Substance Use Disorders (DP1- Clinical Trial Not Allowed) Apply for RFA DA 24 007 Funding Number: RFA DA 24 007 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Avenir Award Program for Genetics or Epigenetics of Substance Use Disorders (DP1 Clinical Trial Optional) Apply for PAR 23 021 Funding Number: PAR 23 021 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Comprehensive Partnerships to Advance Cancer Health Equity (CPACHE) (U54 Clinical Trial Optional) Apply for PAR 22 249 Funding Number: PAR 22 249 Agency: National Institutes of Health Category: Education, Health Funding Amount: $2,000,000 |
| Feasibility Studies to Build Collaborative Partnerships in Cancer Research (P20 Clinical Trial Not Allowed) Apply for PAR 22 239 Funding Number: PAR 22 239 Agency: National Institutes of Health Category: Education, Health Funding Amount: $375,000 |
| Precompetitive Collaboration on Liquid Biopsy for Early Cancer Assessment: Liquid Biopsy Research Laboratories (U01 Clinical Trial Not Allowed) Apply for RFA CA 23 018 Funding Number: RFA CA 23 018 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| Functional Validation and/or Characterization of Genes or Variants Implicated in Substance Use Disorders (R21/R33 Clinical Trial Not Allowed) Apply for PAR 23 041 Funding Number: PAR 23 041 Agency: National Institutes of Health Category: Education, Health Funding Amount: $125,000 |
| Precompetitive Collaboration on Liquid Biopsy for Early Cancer Assessment: Data Management and Coordinating Unit (U24 Clinical Trial Not Allowed) Apply for RFA CA 23 019 Funding Number: RFA CA 23 019 Agency: National Institutes of Health Category: Education, Health Funding Amount: $450,000 |
| Targeting Inflammasomes in Substance Abuse and HIV (R01 Clinical Trial Not Allowed) Apply for RFA DA 24 003 Funding Number: RFA DA 24 003 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Targeting Inflammasomes in Substance Abuse and HIV (R21 Clinical Trial Not Allowed) Apply for RFA DA 24 004 Funding Number: RFA DA 24 004 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Investigating the Effects of Addictive Substances on Brain Developmental Trajectories Using Innovative Scalable Methods for Quantification of Cell Identity, Lineage and Connectivity (R01 - Clinical Trial Not Allowed) Apply for RFA DA 23 036 Funding Number: RFA DA 23 036 Agency: National Institutes of Health Category: Education, Health Funding Amount: $700,000 |
| Transformative Educational Advancement and Mentoring Network (TEAM) (R25 Clinical Trial Not Allowed) Apply for RFA CA 23 013 Funding Number: RFA CA 23 013 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| HEAL Initiative: Sleep Predictors of Opioid-Use Disorder Treatment Outcomes Program (R01 Clinical Trial Optional) Apply for RFA DA 23 059 Funding Number: RFA DA 23 059 Agency: National Institutes of Health Category: Education, Health Funding Amount: $3,000,000 |
| HEAL Initiative - Sleep Predictors of Opioid-Use Disorder Treatment Outcomes Program: Leadership and Data Co-ordinating Center (U01 Clinical Trial Optional) Apply for RFA DA 23 060 Funding Number: RFA DA 23 060 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,500,000 |
| Exploratory studies to investigate mechanisms of HIV infection, replication, latency, and/or pathogenesis in the context of substance use disorders (R61/R33 - Clinical Trial Not Allowed) Apply for RFA DA 24 002 Funding Number: RFA DA 24 002 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| NCI Cancer Screening Research Network: ACCrual, Enrollment, and Screening Sites (ACCESS) Hub (UG1 Clinical Trial Required) Apply for RFA CA 23 020 Funding Number: RFA CA 23 020 Agency: National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| NCI Cancer Screening Research Network: Statistics and Data Management Center (UG1 Clinical Trial Required) Apply for RFA CA 23 021 Funding Number: RFA CA 23 021 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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