Opportunity Information: Apply for RFA CA 22 057
The National Cancer Institute (NCI), part of the National Institutes of Health (NIH), is offering an R21 grant opportunity titled "Basic/Translational Research on Health Disparities in Underrepresented People Living with HIV (PLWH) and Cancer (R21 Clinical Trial Not Allowed)" under funding opportunity number RFA-CA-22-057 (CFDA 93.396). This opportunity supports discretionary grant funding in the broad areas of health and education, with a specific scientific focus on understanding why cancer burdens and outcomes differ in people living with HIV who are also members of underrepresented minority groups.
The central purpose of the announcement is to fund basic mechanistic and translational research that examines how HIV interacts with the conditions that create or worsen health disparities to influence cancer development and outcomes. The emphasis is on biological interactions: projects should dig into the mechanisms by which HIV, in combination with disparity-related factors, contributes to the initiation and progression of both AIDS-defining cancers and non-AIDS-defining cancers, as well as the downstream disease complications and pathogenic sequelae that follow. In practical terms, the NCI is looking for studies that can connect disparities and HIV biology to cancer risk, tumor behavior, immune or inflammatory changes, co-infections, treatment responses, or other mechanistically grounded pathways that could explain unequal cancer outcomes in these populations.
The grant mechanism is the NIH R21, which is commonly used to support exploratory and developmental projects that may be higher-risk but have the potential to open new directions for the field. The announcement explicitly states "Clinical Trial Not Allowed," meaning applicants should not propose studies that meet the NIH definition of a clinical trial. The intent is to keep the work in the realm of basic and translational research rather than interventional testing in human subjects designed to evaluate health outcomes. That said, translational studies can still include work that bridges laboratory findings toward human relevance, as long as the proposed research does not constitute a clinical trial.
Eligibility is broad and includes many kinds of organizations that might be positioned to address HIV, cancer, and disparity-focused research. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; and both federally recognized Native American tribal governments and other tribal organizations that are not federally recognized. The opportunity is also open to public housing authorities/Indian housing authorities, nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education), for-profit organizations (other than small businesses), and small businesses. In addition, the announcement highlights other eligible applicants such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations). This breadth signals an interest in drawing on institutions and partnerships that are closely connected to underrepresented communities and the real-world contexts in which disparities are produced and experienced.
Key administrative details include an original closing date of December 15, 2023, and an award ceiling listed as $275,000. The posting indicates expected awards but does not provide a specific number in the provided source text. The opportunity was created on October 3, 2022. Overall, this FOA is aimed at catalyzing mechanistic and translational insights into how HIV and disparity-related factors combine to drive unequal cancer outcomes in underrepresented populations, with the longer-term goal of building a stronger biological foundation for future prevention, diagnosis, and treatment strategies that can reduce cancer health disparities among people living with HIV.Apply for RFA CA 22 057
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Basic/Translational Research on Health Disparities in Underrepresented People Living with HIV (PLWH) and Cancer (R21 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.396.
- This funding opportunity was created on 2022-10-03.
- Applicants must submit their applications by 2023-12-15. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $275,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Basic/Translational Research on Health Disparities in Underrepresented People Living with HIV (PLWH) and Cancer (R21 Clinical Trial Not Allowed)."
Which agency is offering this funding opportunity?
The National Cancer Institute (NCI), which is part of the National Institutes of Health (NIH), is offering this grant opportunity.
What is the funding opportunity number (FOA)?
The funding opportunity number is RFA-CA-22-057.
What is the CFDA number listed for this opportunity?
The opportunity lists CFDA 93.396.
What grant mechanism is being used?
This is an NIH R21 mechanism, which is commonly used for exploratory and developmental research projects.
What is the main purpose of this FOA?
The FOA aims to fund basic mechanistic and translational research to understand why cancer burdens and outcomes differ for people living with HIV who are also members of underrepresented minority groups.
What scientific areas does the FOA emphasize?
The focus is on biological and mechanistic explanations for disparities in cancer risk and outcomes among underrepresented people living with HIV, including how HIV interacts with disparity-related conditions to influence cancer development, progression, and downstream complications.
What types of cancers are within scope?
The FOA includes both AIDS-defining cancers and non-AIDS-defining cancers, along with related downstream disease complications and pathogenic sequelae.
What kinds of research questions or pathways are specifically encouraged?
Projects are expected to connect HIV biology and disparity-related factors to mechanistically grounded pathways that may explain unequal cancer outcomes, such as cancer risk, tumor behavior, immune or inflammatory changes, co-infections, treatment responses, or related biological mechanisms.
Is this opportunity focused on basic research, translational research, or both?
Both. The FOA supports basic mechanistic research and translational research, as long as the work remains non-clinical-trial in nature.
Are clinical trials allowed under this FOA?
No. The FOA is explicitly labeled "Clinical Trial Not Allowed," meaning applicants should not propose studies that meet the NIH definition of a clinical trial.
If clinical trials are not allowed, can studies still use human-related translational approaches?
Yes. Translational work that bridges laboratory findings toward human relevance may be appropriate as long as the proposed research does not constitute a clinical trial (i.e., it is not an interventional study designed to evaluate health outcomes).
What populations are central to this funding opportunity?
The FOA centers on underrepresented people living with HIV (PLWH) who also experience cancer disparities, with attention to underrepresented minority groups and the conditions that create or worsen health disparities.
What kinds of organizations are eligible to apply?
Eligibility is broad and includes many organization types, spanning government entities, educational institutions, tribal entities, nonprofits, for-profits, small businesses, and foreign organizations, among others.
Are state and local government entities eligible applicants?
Yes. Eligible applicants include state governments, county governments, city or township governments, and special district governments.
Are public and private higher education institutions eligible?
Yes. Public and state-controlled institutions of higher education and private institutions of higher education are eligible.
Are tribal governments and tribal organizations eligible?
Yes. Federally recognized Native American tribal governments are eligible, and other tribal organizations (not federally recognized) are also eligible.
Are U.S. territories or possessions eligible?
Yes. The FOA lists U.S. territories or possessions as eligible applicants.
Are non-U.S. entities allowed to apply?
Yes. The FOA indicates that non-U.S. entities (foreign organizations) are eligible.
Are nonprofits eligible to apply?
Yes. Nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education) are eligible.
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are listed as eligible, and small businesses are also eligible.
Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are included among eligible applicants.
Are faith-based and community-based organizations eligible?
Yes. The FOA highlights faith-based or community-based organizations as eligible applicants.
Are minority-serving institutions specifically included?
Yes. The FOA highlights multiple categories, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are federal agencies eligible to apply?
Yes. The FOA lists eligible federal agencies among the eligible applicant types.
What is the maximum award amount mentioned?
The posting lists an award ceiling of $275,000.
How many awards does NCI expect to make?
The provided information indicates that expected awards are mentioned, but a specific number of awards is not provided in the source text included here.
What was the original application closing date?
The original closing date listed is December 15, 2023.
When was this opportunity created?
The opportunity was created on October 3, 2022.
What broad areas of funding does this opportunity fall under?
The opportunity supports discretionary grant funding in the broad areas of health and education, with a specific scientific focus on cancer disparities among underrepresented people living with HIV.
What is the longer-term goal of funding this research?
The FOA seeks to build a stronger biological foundation that can inform future prevention, diagnosis, and treatment strategies aimed at reducing cancer health disparities among people living with HIV.
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