Opportunity Information: Apply for PA 23 044
The NIH funding opportunity PA 23-044, titled "Urgent Competitive Revision to Existing NIH Grants and Cooperative Agreements (Urgent Supplement Clinical Trial Optional)," is designed to quickly add funding to certain active NIH awards when an unexpected public health crisis creates immediate, time-sensitive research needs. The key idea is that some urgent circumstances cannot be anticipated at the time a new application, renewal application, or standard non-competing progress report is submitted, and this mechanism gives NIH a way to support rapid, targeted changes in scope or activities through a competitive revision. In practice, this is aimed at enabling researchers to pivot or expand ongoing, already-funded projects so they can contribute to a pressing public health response without waiting for a full new grant cycle.
This opportunity is only relevant to investigators and institutions that already hold specific eligible NIH research grants or cooperative agreements, as detailed in the full Funding Opportunity Announcement. Rather than being reviewed through a standard centralized route, applications for these urgent competitive revisions are sent directly to the NIH Institute, Center, or other awarding component that manages the parent award, meaning the application is tied to the existing grant and reviewed in the context of that grant's objectives, structure, and administrative home. The "clinical trial optional" label indicates that proposed activities may include a clinical trial, but a clinical trial is not required; applicants can propose either clinical or non-clinical work as long as it fits the urgent public health purpose and aligns appropriately with the parent award.
The opportunity is listed as a discretionary grant program under the NIH, with a health-related activity category and CFDA number 93.866. It is broadly open in terms of applicant organizational type, covering many common government, academic, nonprofit, and private-sector entities, but the defining eligibility requirement is connection to an eligible active NIH award. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (other than higher education institutions); for-profit organizations (other than small businesses); small businesses; and other organizations that meet NIH criteria. The FOA also explicitly highlights additional eligible categories such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-U.S. (foreign) entities, reflecting NIH's intent to allow a wide range of organizations to contribute when an urgent public health need arises.
In terms of timing, the opportunity has an original closing date listed as 2025-10-25, and it was created on 2022-10-31. The listing does not provide an award ceiling or expected number of awards in the summary fields provided, which usually means applicants need to consult the full FOA and the relevant NIH awarding Institute or Center to understand typical budget expectations, allowable costs, and any limits or urgency-driven constraints. Overall, PA 23-044 functions as a rapid-response supplement pathway for existing NIH-funded projects, letting NIH and funded investigators adjust quickly to emerging public health emergencies by competitively requesting additional resources and revised activities under the umbrella of an already-supported research program.Apply for PA 23 044
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Urgent Competitive Revision to Existing NIH Grants and Cooperative Agreements (Urgent Supplement Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on 2022-10-31.
- Applicants must submit their applications by 2025-10-25. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIH PA 23-044 Urgent Competitive Revision to Existing NIH Grants and Cooperative Agreements (Urgent Supplement Clinical Trial Optional)
What is NIH PA 23-044?
PA 23-044 is an NIH funding opportunity for an urgent competitive revision to an existing, active NIH research grant or cooperative agreement. Its purpose is to quickly add funding so an already-funded project can respond to an unexpected public health crisis that creates immediate, time-sensitive research needs.
What problem is this opportunity meant to solve?
Some urgent public health situations cannot be anticipated when a new application, renewal application, or standard non-competing progress report is submitted. PA 23-044 provides a way for NIH to support rapid, targeted changes in scope or activities through a competitive revision, rather than waiting for a full new grant cycle.
Is this a new standalone NIH grant?
No. This opportunity is designed to support competitive revisions to existing NIH awards. The application is tied to a current parent award and is considered in the context of that award.
Who is this opportunity intended for?
It is intended for investigators and institutions that already hold specific eligible active NIH research grants or cooperative agreements, as detailed in the full Funding Opportunity Announcement (FOA).
What is the key eligibility requirement?
The defining eligibility requirement is a connection to an eligible active NIH award. While many organization types are broadly eligible, the applicant must be able to submit the request as a competitive revision to a qualifying parent award.
Can organizations without an existing NIH award apply?
Not under this mechanism, based on the summary provided. PA 23-044 is relevant only when there is an eligible active NIH parent award that the competitive revision would modify.
What kinds of projects does this support?
It supports rapid, targeted changes to an ongoing project so the funded research can pivot or expand to address a pressing public health response. The proposed urgent activities must align appropriately with the parent award.
Does the revised work have to be within the scope of the parent grant?
The description indicates the request is reviewed in the context of the parent award's objectives and structure, and is meant to support changes in scope or activities for an urgent need. The proposed activities should be aligned appropriately with the parent award and tied to the urgent public health purpose.
What does "Urgent Supplement" mean in practical terms?
In practical terms, NIH is using a competitive revision pathway to quickly add resources so an existing project can respond to an emerging crisis without waiting for a new grant competition cycle.
What does "clinical trial optional" mean?
"Clinical trial optional" means the proposed urgent activities may include a clinical trial, but a clinical trial is not required. Applicants can propose clinical or non-clinical work, as long as it fits the urgent public health purpose and aligns with the parent award.
Is a clinical trial required to apply?
No. The opportunity explicitly states clinical trials are optional.
Where is the application submitted?
Applications are sent directly to the NIH Institute, Center, or other awarding component that manages the parent award. This is not described as going through a standard centralized review route in the provided summary.
Who reviews the application?
Based on the information provided, the application is reviewed by the NIH awarding component that manages the parent award, and it is reviewed in the context of that parent award's objectives, structure, and administrative home.
Which NIH component should an applicant contact or work with?
The relevant NIH Institute, Center, or other awarding component is the one that manages the parent award. The application is tied to that component.
What is the CFDA number for this opportunity?
The listing identifies CFDA 93.866.
How is this opportunity categorized?
It is listed as a discretionary grant program under NIH, with a health-related activity category.
What applicant organization types are eligible?
The opportunity is broadly open by organization type, including:
- State, county, city/township, and special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Native American tribal organizations (not federally recognized as governments)
- Public housing authorities and Indian housing authorities
- Nonprofits with or without 501(c)(3) status (other than higher education institutions)
- For-profit organizations (other than small businesses)
- Small businesses
- Other organizations that meet NIH criteria
The FOA also explicitly highlights additional eligible categories such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. (foreign) entities.
Are non-U.S. (foreign) organizations eligible?
Yes, the summary indicates that non-U.S. (foreign) entities are included among the explicitly highlighted eligible categories, subject to NIH criteria and the requirement that the request ties to an eligible active NIH parent award.
Are U.S. territories or possessions eligible to apply?
Yes, U.S. territories or possessions are explicitly highlighted as eligible in the description provided.
Are federal agencies eligible applicants?
Yes, the summary explicitly includes eligible federal agencies among the highlighted eligible categories.
Is there an award ceiling listed?
No. The summary fields provided do not list an award ceiling.
Is the expected number of awards listed?
No. The summary fields provided do not list an expected number of awards.
How should applicants understand budget expectations or limits?
Because the summary does not provide an award ceiling or expected number of awards, applicants typically need to consult the full FOA and coordinate with the relevant NIH awarding Institute/Center to understand typical budget expectations, allowable costs, and any urgency-driven constraints.
When was this opportunity created?
The listing indicates it was created on 2022-10-31.
What is the closing date for this opportunity?
The listing shows an original closing date of 2025-10-25.
What is the main benefit of using this mechanism instead of applying for a new grant?
The main benefit is speed and relevance: it allows NIH-funded investigators to pivot or expand an ongoing project quickly to contribute to an urgent public health response, without waiting for the timeline of a new grant cycle.
How is this opportunity different from a standard progress report or renewal?
It is designed for urgent circumstances that were not anticipated at the time of the new application, renewal application, or standard non-competing progress report. It provides a pathway for a competitive revision to add funding and adjust activities quickly.
Does the application have to relate to an "unexpected public health crisis"?
Yes. The core purpose is to address unexpected public health crises that create immediate, time-sensitive research needs.
Is the request tied to the existing grant's administrative home?
Yes. The application is submitted to and handled by the NIH awarding component that manages the parent award, and it is reviewed in the context of that award.
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