Urgent Competitive Revision to Existing NIH Grants and Cooperative Agreements (Urgent Supplement Clinical Trial Optional) | PA 23 044

Opportunity Information: Apply for PA 23 044

The NIH funding opportunity PA 23-044, titled "Urgent Competitive Revision to Existing NIH Grants and Cooperative Agreements (Urgent Supplement Clinical Trial Optional)," is designed to quickly add funding to certain active NIH awards when an unexpected public health crisis creates immediate, time-sensitive research needs. The key idea is that some urgent circumstances cannot be anticipated at the time a new application, renewal application, or standard non-competing progress report is submitted, and this mechanism gives NIH a way to support rapid, targeted changes in scope or activities through a competitive revision. In practice, this is aimed at enabling researchers to pivot or expand ongoing, already-funded projects so they can contribute to a pressing public health response without waiting for a full new grant cycle.

This opportunity is only relevant to investigators and institutions that already hold specific eligible NIH research grants or cooperative agreements, as detailed in the full Funding Opportunity Announcement. Rather than being reviewed through a standard centralized route, applications for these urgent competitive revisions are sent directly to the NIH Institute, Center, or other awarding component that manages the parent award, meaning the application is tied to the existing grant and reviewed in the context of that grant's objectives, structure, and administrative home. The "clinical trial optional" label indicates that proposed activities may include a clinical trial, but a clinical trial is not required; applicants can propose either clinical or non-clinical work as long as it fits the urgent public health purpose and aligns appropriately with the parent award.

The opportunity is listed as a discretionary grant program under the NIH, with a health-related activity category and CFDA number 93.866. It is broadly open in terms of applicant organizational type, covering many common government, academic, nonprofit, and private-sector entities, but the defining eligibility requirement is connection to an eligible active NIH award. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (other than higher education institutions); for-profit organizations (other than small businesses); small businesses; and other organizations that meet NIH criteria. The FOA also explicitly highlights additional eligible categories such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-U.S. (foreign) entities, reflecting NIH's intent to allow a wide range of organizations to contribute when an urgent public health need arises.

In terms of timing, the opportunity has an original closing date listed as 2025-10-25, and it was created on 2022-10-31. The listing does not provide an award ceiling or expected number of awards in the summary fields provided, which usually means applicants need to consult the full FOA and the relevant NIH awarding Institute or Center to understand typical budget expectations, allowable costs, and any limits or urgency-driven constraints. Overall, PA 23-044 functions as a rapid-response supplement pathway for existing NIH-funded projects, letting NIH and funded investigators adjust quickly to emerging public health emergencies by competitively requesting additional resources and revised activities under the umbrella of an already-supported research program.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Urgent Competitive Revision to Existing NIH Grants and Cooperative Agreements (Urgent Supplement Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
• This funding opportunity was created on 2022-10-31.
• Applicants must submit their applications by 2025-10-25. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PA 23 044

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